Small Animal Imaging
Myocardial uptake of 18F-FDG may hamper visualization of lung lesions caused in mice models. Two approaches have been proposed for reducing myocardial uptake in these preclinical studies, namely, calcium channel blockers (verapamil) and high-fat diets such as commercial ketogenic diets and sunflower seed diets. The objective of this study was to compare the efficacy of these approaches in reducing myocardial uptake of 18F-FDG in mice. These images represent four different levels of myocardium uptake for the different treatments evaluated in this study.
PLoS ONE 9(9): e107999. doi:10.1371/journal.pone.0107999
Applications in oncology
PET/CT images of mice and rat xenotransplant and transgenic models. CT images are used for the precise location and segmentation of the tumor volumes, while tumor activity is obtained from the PET images.
Am J Pathol. 2009 Feb;174(2):602-12. doi: 10.2353/ajpath.2009.080636
