Latest publications and patents
Papers
2020
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"A radiological score for the assessment of tuberculosis progression: Validation in mouse models", Ortega-Gil, A., A. Munoz-Barrutia, J. J. Roca, L. Guijarro-Lopez, and J. J. Vaquero. 2020, Tuberculosis (Edinb), 121: 101918.
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"Optical Properties of Tissues in the Near Infrared: Their Relevance for Optical Bioimaging", Marcos-Vidal, Asier, Juan José Vaquero, and Jorge Ripoll. 2020. Near Infrared-Emitting Nanoparticles for Biomedical Applications (Springer, Cham).
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"Real-Time 3D PET Image with Pseudoinverse Reconstruction", López-Montes, Alejandro, Pablo Galve, José Manuel Udias, Jacobo Cal-González, Juan José Vaquero, Manuel Desco, and Joaquín L Herraiz. 2020.Applied Sciences, 10: 2829.
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"Simplified Statistical Image Reconstruction for X-ray CT With Beam-Hardening Artifact Compensation", Abella, M., C. Martinez, M. Desco, J. J. Vaquero, and J. A. Fessler. 2020. IEEE Trans Med Imaging, 39: 111-18.
2019
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"SiPM-based PET detector module for a 4π span scanner", Perez-Benito, D, R Chil, JM Udias, M Desco, and JJ Vaquero. 2019. , Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 936: 18-21.
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"X-ray-based virtual slicing of TB-infected lungs", Ortega-Gil, A., J. J. Vaquero, M. Gonzalez-Arjona, J. Rullas, and A. Munoz-Barrutia. 2019. Sci Rep, 9: 19404.
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"Computed Tomography-Based Biomarker for Longitudinal Assessment of Disease Burden in Pulmonary Tuberculosis", Gordaliza, P. M., A. Munoz-Barrutia, L. E. Via, S. Sharpe, M. Desco, and J. J. Vaquero. 2019. , Mol Imaging Biol, 21: 19-24.
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"Applications of Light-Sheet Microscopy in Microdevices", Albert-Smet, I., A. Marcos-Vidal, J. J. Vaquero, M. Desco, A. Munoz-Barrutia, and J. Ripoll. 2019. Front Neuroanat, 13: 1.
2018
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“Unsupervised CT Lung Image Segmentation of a Mycobacterium Tuberculosis Infection Model”, P. M. Gordaliza, A. Muñoz-Barrutia, M. Abella, M. Desco, S. Sharpe, and J. J. Vaquero, Sci. Rep., vol. 8, no. 1, p. 9802
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“Improving PET Quantification of Small Animal [68Ga]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction”, J. Cal-Gonzalez et al., Mol. Imaging Biol., vol. 20, no. 4, pp. 584–593
2017
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“Optimized CUBIC protocol for 3D imaging of chicken embryos at single-cell resolution,” Development, Apr. 2017, doi:10.1242/dev.145805.
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"Sub-surface laser engraving techniques for scintillator crystals: methods, applications and advantages", IEEE Transactions on Radiation and Plasma Medical Sciences, DOI 10.1109/TRPMS.2017.2714265
2016
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“Evaluation of PeneloPET Simulations of Biograph PET/CT Scanners,” IEEE Trans. Nucl. Sci., vol. 63, no. 3, pp. 1367–1374, Jun. 2016, DOI: 10.1109/TNS.2016.2527789.
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“Experimental validation of gallium production and isotope-dependent positron range correction in PET,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip., vol. 814, pp. 110–116, 2016, DOI: 10.1016/j.nima.2016.01.013.
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“Automatic Cardiac Self-Gating of Small-Animal PET Data,” Mol. Imaging Biol., vol. 18, no. 1, pp. 109–116, Feb. 2016, DOI: 10.1007/s11307-015-0868-y.
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“Functional segmentation of dynamic PET studies: Open source implementation and validation of a leader-follower-based algorithm,” Comput. Biol. Med., vol. 69, pp. 181–188, Feb. 2016, DOI: 10.1016/j.compbiomed.2015.12.012.
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“3D imaging in CUBIC-cleared mouse heart tissue: going deeper,” Biomed. Opt. Express, vol. 7, no. 9, pp. 3716–3720, Sep. 2016, DOI: 10.1364/BOE.7.003716.
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“Design and Development of a Wireless Infrared EEG Recorder for chicken embryos,” 2016 IEEE Int. Symp. Med. Meas. Appl., pp. 487–492, 2016.
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“3D imaging of the cleared intact murine colon with light sheet microscopy,” SPIE BiOS, p. 97130Q, 2016, DOI: 10.1117/12.2212039.
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“Tissue-Dependent and Spatially-Variant Positron Range Correction in 3D PET,” IEEE Trans. Med. Imaging, vol. 35, no. 1, pp. 369–369, Jan. 2016, DOI: 10.1109/TMI.2015.2511958.
2015
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“Positron Emission Tomography: Current Challenges and Opportunities for Technology Advances in Clinical and Pre-Clinical Imaging Systems”, Annual Review of Biomedical Engineering, Vol. 17, pp 385–414, December 2015
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“Tissue-Dependent and Spatially-Variant Positron Range Correction in 3D PET”, IEEE Transactions On Medical Imaging, vol. 34, no. 11, Nov 2015
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“Fluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementation”, Proc. of SPIE Vol. 9531 953111-1
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“Automatic Cardiac Self-Gating of Small-Animal PET Data”, Mol Imaging Biol, DOI: 10.1007/s11307-015-0868-y, 2015
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“Recovery and normalization of triple coincidences in PET”, Medical Physics, vol. 42, no. 3, pp. 1398-1401, doi: 10.1118/1.4908226, 2015
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“Development and validation of an open source quantification tool for DSC-MRI studies”, Computers in Biology and Medicine, vol. 58, pp. 56–62, doi: 10.1016/j.compbiomed.2015.01.002, 2015
2014
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“Application of the compressed sensing technique to self-gated cardiac cine sequences in small animals”, Magn Reson Med. Aug;72(2):369-80. doi: 10.1002/mrm.24936, 2014
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“Comparison of methods to reduce myocardial 18F-FDG uptake in mice: calcium channel blockers versus high-fat diets”, PLoS One. 2014 Sep 19;9(9):e107999. doi: 10.1371/journal.pone.0107999, 2014
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“Dual-exposure technique for extending the dynamic range of x-ray flat panel detectors”, Phys. Med. Biol., vol. 59, pp. 421–439, doi: 10.1088/0031-9155/59/2/421, 2014
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“Modification of the TASMIP x-ray spectral model for the simulation of microfocus x-ray sources”, Med. Phys., vol. 41, pp. 011902, doi: 10.1118/1.4837220, 2014
2013
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”jClustering, a n Open Framework for the Development of 4D Clustering Algorithms”, PLoS One, vol. 8, no. 8, doi: 10.1371/journal.pone.0070797, 2013
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“Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template” Computer Methods And Programs In Biomedicine, vol. 111, no. 2, pp.308-314, doi: 10.1016/j.cmpb.2013.04.010, 2013
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“MRI compatibility of position-sensitive photomultiplier depth-of-interaction PET detectors modules for in-line multimodality preclinical studies”, Nuclear Instruments and Methods in Physics Research A, vol. 702, pp. 83-87, 2013
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"Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography". J Biomed Opt, 18(7): 076016 (8 pp), 2013
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"Positron range estimations with PeneloPET". Phys Med Biol, 58(15): 5127-5152, 2013
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"Monte Carlo study of the effects of system geometry and antiscatter grids on cone-beam CT scatter distributions". Med Phys, 40: 051915 (19pp), 2013
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"Improved dead-time correction for PET scanners: application to small-animal PET". Phys Med Biol, 58(7): 2059-2072, 2013
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"Massively parallelizable list-mode reconstruction using a Monte Carlo-based elliptical Gaussian model". Med Phys, 40(1): 012504 (11pp), 2013
2012
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“A method for small-animal PET/CT alignment calibration”, Phys. Med. Biol. 57 N199-N207–7518, 2012
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“Misalignments calibration in small-animal PET scanners based on rotating planar detectors and parallel-beam geometry”, Phys. Med. Biol. 57 7493–7518, 2012
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“Approach to Assessing Myocardial Perfusion in Rats Using Static [13N]-Ammonia Images and a Small-Animal PET”, Molecular Imaging and Biology, vol. 14, pp. 541-545, 2012
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“Accuracy of CT-based attenuation correction in PET/CT bone imaging”, Phys. Med. Biol., vol. 57, pp. 2477–2490, 2012
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“NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems”, J Nuc Med, Vol. 53, no. 8, pp. 1300-1309, 2012
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“Waking-like brain function in embryos”, Current Biology, vol. 22, pp. 852-861, 2012
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“Software architecture for multi-bed FDK-based reconstruction in X-ray CT scanners”, Computer Methods and Programs in Biomedicine, vol. 107, pp. 218-232, 2012
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“A method for small-animal PET/CT alignment calibration”, Phys Med Biol, Vol. 57, pp. 199–207, 2012
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"Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data", J Biomed Opt 17, 036013, DOI:10.1117/1.JBO.17.3.036013, 2012
2011
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“GPU-Based Fast Iterative Reconstruction of Fully 3D PET Sinograms”, IEEE Transactions on Nuclear Science, vol. 58, no. 5, pp. 2257-2263, 2011
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“Fully 3D GPU PET reconstruction”, Nuclear Instruments and Methods in Physics Research A, vol. 648, pp. S169-S171, 2011
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“Study of CT-based positron range correction in high resolution 3D PET imaging”, Nuclear Instruments and Methods in Physics Research A, vol. 648, pp. S172-S175, 2011
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“Fluorescence diffuse optical tomography using the split Bregman method”, Med Phys 38, 6275-84, 2011
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"Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information", Biomedical Optics Express 2(9), 2632–2648, 2011
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“Feasibility of U-curve method to select the regularization parameter for fluorescence diffuse optical tomography in phantom and small animal studies”, Optics Express, vol. 19, no. 12, pp. 11490-11506, 2011
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“Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain”, Molecular Imaging and Biology, vol. 13, no. 3, pp. 411-415, 2011
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“NEMA NU 4-2008 Performance Measurements of Two Commercial Small-Animal PET Scanners: ClearPET and rPET-1”, IEEE Transactions on Nuclear Science, vol. 58, no. 1, pp. 58-65, 2011
2010
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“Effects of the super bialkali photocathode on the performance characteristics of a position-sensitive depth-of-interaction PET detector module”, IEEE Transactions on Nuclear Science, vol. 57, no. 5, pp. 2437-2441, 2010
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“A SPECT Scanner for Rodent Imaging Based on Small-Area Gamma Cameras”, IEEE Transactions on Nuclear Science, vol. 57, no. 5, pp. 2524-2531, 2010
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“Data acquisition electronics for gamma ray emission tomography using width-modulated leading-edge discriminators”, Phys Med Biol, 55(15): 4291-4308, 2010
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“Performance evaluation of SiPM photodetectors for PET imaging in the presence of magnetic fields”, Nuclear Instruments and Methods in Physics Research A, vol. 613, pp. 308–316, 2010
2009
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M. Abella, J.J. Vaquero, M.L. Soto-Montenegro, E. Lage, M. Desco. “Sinogram bow-tie filtering in FBP PET reconstruction”, Med Phys, 36(5): 1663-1671, 2009
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“Design and performance evaluation of a coplanar multimodality scanner for rodent imaging”, Phys Med Biol, 54(18): 5427-5441, 2009
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“The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs”, Am J Pathol, 174(2): 602-612, 2009
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“Automated Method for Small-Animal PET Image Registration with Intrinsic Validation”, Molecular Imaging and Biology, vol. 11, pp. 107-113, Mar 2009
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“Assessment of airway distribution of transnasal solutions in mice by PET/CT imaging”, Molecular Imaging and Biology, 11(4):263-268, 2009
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“PeneloPET, a Monte Carlo PET simulation tool based on PENELOPE: features and validation”, Phys Med Biol, 54: 1723-1742, 2009
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“Detection of Visual Activation in the Rat Brain Using 2-deoxy-2-[18F]fluoro-D-glucose and Statistical Parametric Mapping (SPM)”, Molecular Imaging and Biology, vol. 11, pp. 94-99, 2009
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“Automatic Quantification of Histological Studies in Allergic Asthma”, Cytom Part A, 75A(3): 271-277, 2009
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“Research at the Medical Imaging Laboratory, CIBERSAM CB07/09/0031”, Eur J Psychiat, 23(Supl.): 43-48, 2009
2008
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“Real-time digital timing in positron emission tomography”, IEEE Trans Nucl Sci, vol. 55, no. 5, pp. 2531-2540, 2008
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“Assessment of a New High-Performance Small-Animal X-ray Tomograph”, IEEE Trans Nucl Sci, 55(3), pp. 898-905, 2008
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"Extraction of the respiratory signal from small-animal CT projections for a retrospective gating method". Phys Med Biol, 53, pp. 4683-4695, 2008
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“Augmented acquisition of cocaine self-administration and altered brain glucose metabolism in adult female but not male rats exposed to a cannabinoid agonist during adolescence”, Neuropsychopharmacol, 33(4):806-13, Mar, 2008
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“High resolution image in bone biology II. Review of the literature”, Med Oral Patol Oral Cir Bucal; Jan1;13(1):E31-5, 2008
2007
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“High resolution image in bone biology I. Review of the literature”, Med Oral Patol Oral Cir Bucal;12(1):E454-8, 2007
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“Effects of MDMA on blood glucose levels and brain glucose metabolism”, Eur J Nucl Med Mol I, 34(6): 916-925, 2007
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“Noise and physical limits to maximum resolution of PET images”, Nucl Instrum Meth A, 580(2): 934-937, 2007
2006
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“New embedded digital front-end for high resolution PET scanner”, IEEE T Nucl Sci; 53(3): 770-775, 2006
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“FIRST: Fast Iterative Reconstruction Software for (PET) Tomography”. Phys Med Biol; 51(18): 4547-4565, 2006
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“Modeling the acquisition front-end in high resolution gamma-ray imaging”, IEEE T Nucl Sci; 53(3): 1150-1155, 2006
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“Performance Evaluation of the GE Healthcare eXplore VISTA Dual-Ring Small-Animal PET Scanner”, J Nucl Med; 47: 1891-1900, 2006
2005
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“ROC evaluation of statistical wavelet-based analysis of brain activation in [15O]-H2O PET scans”, Neuroimage, 24(3): 763-770, 2005
2004
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“Experiment assessment of mass effects in the rat: implications for small animal PET imaging”, Nuclear Medicine and Biology 31(6): 771-779, 2004
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“Automatic Tuning and Matching of a Small Multifrequency Saddle Coil at 4.7 T”, Magnet Reson Med, 51: 869-873, 2004
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“Method for Bias Field Correction of Brain T1-Weighted Magnetic Resonance Images Minimizing Segmentation Error”, Hum Brain Mapp, 22: 133-144, 2004
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“Resolution recovery in Turbo Spin Echo using segmented Half Fourier acquisition”, Magn Reson Imaging, 22: 369-378, 2004
Book chapters
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A Sisniega, M Desco, JJ Vaquero. “Design and assessment principles of semiconductor Flat-Panel detector based X-Ray micro-CT systems for small animal imaging”. Book chapter in “Integrated Microsystems and Nanotechnology: MEMs, Photonic and Biological Interfaces”, CRC Press, pp. 309-335, ISBN: 978-1-4398-3620-0, 2012
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J Lafuente, JJ Vaquero, J Sánchez. Secuencias en resonancia magnética. In: “Aprendiendo los fundamentos de la Resonancia Magnética”, E Oleaga, J Lafuente, Editorial Médica Panamericana, 2006, pp 33-43. ISBN 84-9835-121-9
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JJ Vaquero. “Medicina nuclear e Imagen Molecular”, in Ingeniería Biomédica e Imágenes Médicas, Ediciones de la Universidad Castilla-La Mancha, 2006, pp145-158, ISBN 84-8427-426-8
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JJ Vaquero. Imagen Molecular. In: Cáncer. P García-Barreno, D Espinós-Pérez and M Cascales-Angosto, Eds. Madrid: Instituto de España, 2003; pp 283-310. ISBN 84-85559-57-6
Patents in exploitation
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Planning System for Intraoperative Radiation Therapy and Method for Carrying out Said Planning, US 2011/0052036 A1, 03/03/2011
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Procedimiento y dispositivo para la detección y discriminación de eventos válidos en detectores de radiación gamma, PCT/ES2009/070456, 26/10/2009
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Incubadora para imagen con radiación no ionizante, WO 2009/077626 A1, 25/06/2009
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Multi-Modality Tomography Apparatus, US 2009/0213983 A1, 27/08/2009
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Sistema de planificación para radioterapia intraoperatoria y procedimiento para llevar a cabo dicha planificación, PCT/ES2008/000240, 14/04/2008, WO 2009/127747 A1, 22/10/2009
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Incubator for non-ionizing radiation imaging, US2011/0125010A1, 19/12/2007
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Incubadora para imagen con radiación no ionizante, PCT/ES2007/070214, 19/12/2007
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Multi-Modality Tomography Apparatus, PCT/ES2006/070150, 26/10/2006
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Tomography scanner with axially discontinuous detector array, PCT/US2004/030656, 20/09/2004
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Compact modular, configurable base for position sensitive photomultipliers, US 6,642,493 B1, 04/11/2003
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A multi-slice PET scanner from side-looking phoswich scintillators, PCT/US98/22875, WO 99/24848, 20/05/1999